Carbohydrates play a key role in numerous biochemical and
biological processes, which include cell differentiation and maturation,
fertilization, and protein folding and degradation. The carbohydrate polymer
branch of study encompasses the potential uses in industrial applications of
carbohydrates, such as in food, paper, adhesives, textiles, biorefining, and
pharmaceuticals.
This article will focus on the development in the field of
carbohydrate binding modular applications in the biotechnological and
pharmaceutical fields.
Introduction
Polysaccharide Polymers
Polysaccharides belong to the class of complex carbohydrates
which is made up of numerous monosaccharide units held together by glycosidic
bonds. Polysaccharide film formation and its mechanical and chemical properties
help find new horizons in pharmaceutical production.
Oligosaccharide Polymers
Furthermore, another class of carbohydrates,
oligosaccharides, is making waves in the field of research and development in
order to manufacture drugs with nutra-ceutical applications.
Carbohydrate-active enzymes (CAZymes) in Polymer Formation
These enzymes are essential in the manufacturing and
breakdown of complex carbohydrates and glyco conjugates. Apart from belonging
in the catalytic domain of enzymes, CAZymes also represent a substrate binding
module, which is collectively known as carbohydrate binding catalytic domain.
Carbohydrate binding Catalytic Domain
This new domain has its own independent functions and folds
in a chemical reaction. Almost 7% of the CAZymes exhibit nearly one
carbohydrate binding module. Currently, fifty eight carbohydrate binding
modules are extensively being studied. They present a considerable amount of
heterogeneity and binding particulars towards crystalline and amorphous
polysaccharides.
Carbohydrate binding Modules and Proteins
These carbohydrate binding modules are famous for initiating
the activity of enzymes by targeting a prolonged interaction with the
substrate. Carbohydrate binding modules are independent of other protein
molecules, thus they make for an excellent option for several applications
which involve enzyme proteolysis and DNA recombinant technology.
Carbohydrates are relatively an untapped resource in the
field of pharmaceutics and drug development due to the extensive technological
expertise required for their analysis, complex bond linkages, and intricate
chemistries between the molecules.
This is why Watson International, an eminent chemical trading company,
has invested time and energy in the research and development of carbohydrate
based pharmaceutical drugs to offer an easier diagnostic and therapeutic option
for the people. Ailments like tuberculosis and diabetes have shown positive
results when treated with carbohydrate based drugs. The company also offers an
array of chemical compounds from precious metal catalysts to cosmetics. For further information,
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